The cart's Podcast

Antibody-peptide

In BsAb repertoire, antibody-peptide conjugates, also referred to as chemically programmed antibodies (cpAbs), are a novel class of pharmaceuticals utilizing small molecules as the navigator instead of mAb.

cancer vaccine

Now cancer vaccine research has aroused the public’s attention. According to a survey by the Cancer Research Institute (CRI), there are more than 300 cancer vaccine candidates in clinical trials across the industry. 

DNA vaccine

Nucleic acid vaccines, genetic vaccines or DNA vaccine, are also known as naked nucleic acid vaccines. At present, there are about 30 kinds of HIV vaccines including recombinant genetic engineering vaccines, nucleic acid vaccines and live attenuated vaccine in various clinical trials around the world.

What is a vaccine

What is a vaccine? The vaccine is an autoimmune preparation for preventing infectious diseases by artificially attenuating, inactivating or using genetic engineering methods for pathogenic microorganisms (such as bacteria, rickettsia, inactivated virus, etc.)

Knobs-into-holes

Triomab binds tumor cells and T cells through the Fv function, and recruits FcR-expressing functional cells. 
Using the steric hindrance effect of the Knobs-into-holes structure allows for the correct assembly of the two different antibody heavy chains.

CrossMab

Some B-region-containing BsAb have an Fc segment attached to them, so they can bind to Fc receptors on cells with killing activity and exert their killing effect on tumor cells. RG7221 and RG7716 are representative products of CrossMab, both of which are anti-Ang-2 / VEGF bispecific antibodies. 

bispecific antibody

A bispecific antibody is an artificial antibody containing two specific antigen binding sites. It can bridge the target cells and functional molecules and stimulate a directed immune response. Bispecific antibodies can bind to two targeting sites, one is the tumor antigen on the surface of tumor cells, and the other is the antigen on the surface of immune cells.

Bispecific antibodies

Bispecific antibodies (BsAbs) are a class of bifunctional antibody hybrid molecules. The Fab segments in bivalent antibodies have different specificities and can bind to different ligands. The BsAb contains two different Fab segments that recognize specific antigens.

HER2 ADC

HER2 ADC targeted therapy has greatly improved the prognosis of HER2-positive breast cancer patients. Whether this combination can express advanced breast cancer for HER2 and patients with non-small cell lung cancer offer a potential new approach to ADC analysis. 

ADC antibody

ADC antibody use a specific linker to link antibodies to small molecule cytotoxic drugs called ADC payload. The main components include antibodies, linkers, and small-molecule cytotoxic drugs (SM). However, some antibodies have anti-tumor pharmacodynamic effects, such as the synergistic effect of ado-trastuzumab and maytansine in Kadcyla.